Yuan-I Chang - National Yang-Ming University, Department & Institute of Physiology

List

Yuan-I Chang

Research Field Publications Research grant Lab intro (2016.07.26 update)

Name

Yuan-I Chang

Position

Assistant Professor

Tel.

+886-2-2826-7312

Fax No.

+886-2-2826-4049

E-mail

ychang@ym.edu.tw

Education

Ph.D. (2010)	Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taiwan
M.S. (1998)	Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taiwan
B.S. (1996)	Department of Animal Science, National Taiwan University, Taiwan

Experience

Assistant Professor (Aug, 2014-present)

Institute of Physiology, National Yang-Ming University, Taiwan

Postdoctoral Fellow (Aug, 2011-Jul, 2014)

McArdle Laboratory for Cancer Research, University of Wisconsin- Madison, US

Postdoctoral Fellow, (Aug, 2010-Jul, 2011)

Department of Surgery, Taipei Veterans General Hospital, Taiwan

Assistant Research Fellow (Jan, 2010-Jul, 2010)

Division of Molecular and Genomic Medicine, National Health Research Institutes (NHRI), Taiwan

Assistant Research Fellow (Apr, 2009-Dec, 2009)

Agricultural Biotechnology Research Center, Academia Sinica, Taiwan

Career military (Sep, 1998-Apr, 2009)

Research Interests:

Epigenetics is the study of cellular and physiological phenotypic trait variations that are caused by external or environmental factors that affect gene expression instead of being caused by changes in the DNA sequence. Now, we are interested in the influence of cytokine-stimulated signal pathways in the activity of DNA methyltransferases (DNMTs), and the consequential impact in hematopoiesis, leukemogenesis and development of drug resistance. In addition, we also try to evaluate the function of DNMTs in somatic cancers, such as colorectal cancer.

Awards and Honors

(1)	Young Scientist Outstanding Research Paper Award, The Hematology Society of Taiwan, Taiwan, 2016
(2)	Outstanding Teacher, School of Medicine, National Yang-Ming University, Taiwan, 2016
(3)	Outstanding problem-based learning (PBL) tutor, Faculty of Medicine, National Yang-Ming University, Taiwan, 2016
(4)	Young Faculty Research Award, Professor Shen Li Yang Medical Education and Research Foundation, Taiwan, 2015
(5)	2014 Scholar-in Training Award, American Association for Cancer Research (AACR), USA, 2014
(6)	2010 Outstanding Poster Award, the 8th Symposium of Bioinformatics and Systems Biology, Taiwan, 2010
(7)	Outstanding Poster Award, Regenerative Medicine 2010: From Stem Cells to Disease Models, Taiwan, 2010
(8)	Graduate Student Oral presentation, the 23th Joint Annual Conference of Biomedical Sciences, Taiwan, 2008
(9)	Outstanding Poster Award, the 16^th Symposium on Recent Advances in Cellular and Molecular Biology, Taiwan, 2008
(10)	Outstanding Poster Award, the Federation of American Societies for Experimental Biology (FASEB) Summer Research Conference: Hematopoietic Malignancies, US, 2007
(11)	Outstanding Student Award/Conference Travel Grant, The Foundation for the Advancement of OutstandingScholarship, Taiwan, 2007

Selected Recent Publications:

1	Chang YI, Kong G, Ranheim EA, Tu PS, Yu YS, Zhang J. Dnmt3a haploinsufficiency cooperates with oncogenic Kras to promote an early-onset T-cell acute lymphoblastic leukemia. Am. J. Transl. Res., 2017 (Acceptance).
2	Chen JL, Ping YH, Tseng MJ, Chang YI, Lee HC, Hsieh RH, Yeh TS. Notch1-promoted TRPA1 expression in erythroleukemic cells suppresses erythroid but enhances megakaryocyte differentiation. Sci. Rep. 7:42883, 2017.
3	Zhang J, Kong G, Rajagopalan A, Lu L, Song J, Hussaini M, Zhang X, Ranheim EA, Liu Y, Wang J, Gao X, Chang YI, Johnson KD, Zhou Y, Yang D, Bhatnagar B, Lucas DM, Bresnick EH, Zhong X, Padron E, Zhang J. p53^-/- synergizes with enhanced NrasG12D signaling to transform megakaryocyte-erythroid progenitors in acute myeloid leukemia. Blood 129:358-370, 2017.
4	Chang YI, Damnernsawad A, Kong G, You X, Wang D, Zhang J. The mystery of oncogenic KRAS: lessons from studying its wild-type counterpart. Small GTPases 22:1-4, 2016 (Invited commentary).
5	Kong G, Chang YI, You X, Ranheim EA, Zhou Y, Burd CE, Zhang J. The ability of endogenous Nras oncogenes to initiate leukemia is codon-dependent. *Leukemia*,30:1935-1938, 2016.
6	Kong G^#, Chang YI^#, Damnernsawad A^#, You X^#, Du J, Ranheim EA, Lee W, Ryu MJ, Zhou Y, Xing Y, Chang Q, Burd CE, Zhang J. Loss of wild-type Kras promotes activation of all Ras isoforms in oncogenic Kras-induced leukemogenesis. *Leukemia, 30:1542-1551, 2016 (^#equal contribution)*
7	Chang YI, You X, Kong G, Ranheim EA, Wang J, Du J, Liu Y, Zhou Y, Ryu MJ, Zhang J. Loss of Dnmt3a and endogenous Kras^G12D/+ cooperate to regulate hematopoietic stem and progenitor cell functions in leukemogenesis. Leukemia, 29: 1847-1856, 2015
8	Johnson KD, Kong G, Gao X, Chang YI, Hewitt KJ, Sanalkumar R, Prathibha R, Ranheim EA, Dewey CN, Zhang J, Bresnick EH. Cis-regulatory mechanisms governing stem and progenitor cell transitions. Sci. Adv., 1: e1500503, 2015
9	Chang YI^#, Damnernsawad A^#, Allen LK, Yang D, Ranheim EA, Young KH, Zhang J, Kong G, Wang J, Liu Y, Fu HY, Yang CS, Guo J, Song H, Zhang J. Evaluation of allelic strength of human TET2 mutations and cooperation between Tet2 knockdown and oncogenic Nras mutation. Br. J. Haematol., 166: 461-465, 2014 (^#equal contribution)
10	Sanalkumar R, Johnson KD, Gao X, Boyer ME, Chang YI, Hewitt KJ, Zhang J, Bresnick EH. Mechanism governing a stem cell-generating cis-regulatory element. Proc. Natl. Acad. Sci. U.S.A., 111: E1091-100, 2014
11	Kong G, Wunderlich M, Yang D, Ranheim EA, Young KH, Wang J, Chang YI, Du J, Liu Y, Tey SR, Zhang X, Juckett M, Mattison R, Damnernsawad A, Zhang J, Mulloy JC, Zhang J. Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm. J. Clin. Invest. 124: 2762-2773, 2014
12	Anderson SA^#, Nizzi CP^#, Chang YI^#, Deck KM, Schmidt PJ, Galy B, Damnernsawad A, Broman AT, Kendziorski C, Hentze MW, Fleming MD, Zhang J, Eisenstein RS. The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption. Cell Metab., 17: 282-290, 2013 (^#equal contribution)
13	Hua WK, Chang YI, Yao CL, Hwang SM, Chang CY, Lin WJ. Protein arginine methyltransferase 1 interacts with and activates p38a to facilitate erythroid differentiation. PLoS One, 8: e56715, 2013
14	Gao X, Johnson KD, Chang YI, Boyer ME, Dewey CN, Zhang J, Bresnick, EH. Gata2 cis-element is required for hematopoietic stem cell generation in the mammalian embryo. J. Exp. Med. 210 (13): 2833-2842, 2013
15	Wang J, Kong G, Liu Y, Du J, Chang YI, Tey SR, Zhang X, Ranheim E, Saba-El-Leil M, Meloche S, Damnernsawad A, Zhang J, Zhang J. Nras^G12D/+ promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions. Blood, 121: 5203-5207, 2013
16	Kong G, Du J, Liu Y, Meline B, Chang YI, Ranheim EA, Wang J, Zhang J. Notch1 mutations target KRAS G12D-expressing CD8+ cells and contribute to their leukemogenic transformation. J. Biol. Chem., 288: 18219-18227, 2013
17	Du J, Liu Y, Meline B, Kong G, Tan LX, Lo JC, Wang J, Ranheim E., Zhang L, Chang YI, Ryu MJ, Zhang J, Zhang J. Loss of CD44 attenuates aberrant GM-CSF signaling in Kras G12D hematopoietic progenitor/precursor cells and prolongs the survival of diseased animals. Leukemia, 27: 754-757, 2013
18	Chang YI, Hsu SC, Chau GY, Huang CY, Sung JS, Hua WK, Lin WJ. Identification of the methylation preference region in heterogeneous nuclear ribonucleoprotein K by protein arginine methyltransferase 1 and its implication in regulating nuclear/cytoplasmic distribution. Biochem. Biophys. Res. Commun., 404: 865-869, 2011
19	Chang YI, Hua WK, Yao CL, Hwang SM, Hung YC, Kuan CJ, Leou JS, Lin WJ. Protein-arginine methyltransferase 1 suppresses megakaryocytic differentiation via modulation of the p38 MAPK pathway in K562 cells. J. Biol. Chem., 285: 20595-20606, 2010
20	Chang YI, Lin SW, Chiou YY, Sung JS, Cheng LC, Lu YL, Sun KH, Chang K, Lin CH, Lin WJ. Establishment of an ectopically expressed and functional PRMT1 for proteomic analysis of arginine-methylated proteins. Electrophoresis, 31: 3834-3842, 2010
21	Wu JM, Jan PS, Yu HC, Haung HY, Fang HJ, Chang YI, Cheng JW, Chen HM. Structure and function of a custom anticancer peptide, CB1a. Peptides, 30: 839-848, 2009
22	Wang WL, Yeh SF, Chang YI, Hsiao SF, Lian WN, Lin CH, Huang CY, Lin WJ. PICK1, an anchoring protein that specifically targets protein kinase Calpha to mitochondria selectively upon serum stimulation in NIH 3T3 cells. J. Biol. Chem., 278: 37705-37712, 2003
23	Lin WJ, Chang YF^#, Wang WL, Huang CY. Mitogen-stimulated TIS21 protein interacts with a protein-kinase-Cα-binding protein rPICK1. Biochem. J., 354: 635-643, 2001. ^#(My first name, Yuan-Fu, was renamed as Yuan-I after this publication)

Research Grants:

1	The effect of DNA methyltransferase in hematopoiesis and its regulatory mechanism (Ministry of Science and Technology, 12/01/2014-10/31/2015)
2	Characterization of genetic alterations involved in oncogenic RAS induced leukemogenesis (Ministry of Science and Technology, 08/01/2015-07/31/2016)
3	Identification of regulatory mechanism of DNA methyltransferase 3A (DNMT3A) in hematopoiesis using phosphoproteomic analysis (Yen Tjing Ling Medical Foundation, 01/01/2016-12/31/2016)
4	Study on the regulatory mechanism of DNA methylation during hematopoiesis (Ministry of Science and Technology, 08/01/2016-07/31/2019)
5	The impact of DNMT3A haploinsufficiency in oncogenic RAS-induced leukemogenesis (Yen Tjing Ling Medical Foundation, 01/01/2017-12/31/2017)

Lab Membership:

Master students:

Yi-Shan Yu & Po-Shu Tu (2014)

Chang-Yi Tsai (2015)

Eric Chang-Yi Lin & Hsiao-Wen Chen (2016)

Ph. D. student:

Yao-Chung Liu (TIGP-MMP, 2016)

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