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National Yang-Ming University, Department & Institute of Physiology

National Yang-Ming University, Department & Institute of Physiology

William J Huang

Research Field    Publications    Research grant    Lab intro    (2012.02.01  update)

Name William J Huang  

 

Position Employ Professor
Tel. 886-2-2875-7519 ext307
Fax No. 886-2-2875-7540
E-mail jshuang@vghtpe.gov.tw
Education

1995-2000 Ph.D. ,Institute of Clinical Medicine, National Yang Ming University

1982-1989 Medical school, China Medical College, M.D.

Experience

2011-          Professor, Department of Urology, National Yang-Ming University

2009-        Section Chief, Clinical Education, Department of Medical Education, Taipei Veterans  General

                    Hospital

2007-          Teaching program director, Department of Surgery, Taipei Veterans General Hospital

2007-           Macy Scholar/ Harvard Medical School, Program for Comprehensive assessment in Health

                    Science Education

2006-           Vice Chairman, Department of Medicine, National Yang-Ming University, School of Medicine

1997-1998   Post-doctoral fellow,      Department of Urology, Baylor College of Medicine, Texas Medical

                    Center, Houston, Texas, USA./ Prof. Larry Lipshultz and Prof. Dorrie Lamb

1994-        Attending Urologist, Urology/Surgery, Taipei Veterans General Hospital

1993-1994   Chief residency Urology, Urology/Surgery, Veterans General Hospital-Taipei

1991-1993   Residency Urology, Urology/Surgery, Veterans General Hospital-Taipei

1989-1991  Residency Surgery, Surgical Department, Veterans General Hospital-Taipei

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Research Interests:
My research interests are in reproductive endocrinology, andrology, and regulation of spermatogenesis. To solve problems in male infertility by using animal models or designed setting of hormonal anomalies is the focus of my investigation. The effects of hyperprolactinemia on male reproductive functions are the main theme of my recent research.top
Selected Recent Publications:

1.

Chen M, Huang YC, Yang S, Hsu JM, Chang YH, Huang WJ, Chen YM.. Common variants at 8q24 are associated with prostate cancer risk in Taiwanese men. Prostate 2010; 70(5):502-507 (SCI).

2.

Huang WJ, Yang LY, Pu HF, Tsai YT, Wang PS. The effects of anti-TNF-α antibody on hyperprolactinemia -related suppression of hCG-induced testosterone release in males rats. Journal of Sexual Medicine 2010;: (SCI).

3.

Hsiao FY, Huang WJ, Chen KK. The exposure of urologists and the treatment for male factor infertility on the websites of ART centers in Taiwan. Journal of Andrology 2010; 32(2):155-8 (SCI).

4.

Lin CC, Huang WJ, Chen KK. Measurement of testicular volume in smaller testes: how accurate is the conventional orchidometer? Journal of Andrology 2010; 30(6):685-689 (SCI).

5.

Cho YM, Pu HF, Huang WJ, Ho LT, Wang SW, Wang PS. Role of Serum- and Glucocorticoid-Inducible Kinase-1 in Regulating Torsion-Induced Apoptosis in Rats. International Journal of Andrology 2011 Aug; 34(4):379-89. (SCI).

6.

Lin YS, Chung HK, Lin ATL, Huang WJ, Huang YH, Lin TP, Chen KK. Laparoscopic partial nephrectomy: Taipei Veterans General Hospital experience. Journal of the Chinese Medical Association 2010; 73(4):194-198 (SCI).

7.

Chen SS, Huang WJ. Differences in biochemical markers and body mass index between patients with and without varicocele. Journal of the Chinese Medical Association 2010; 73(4):194-198 (SCI).

8.

Chen SS, Huang WJ. Experience of Varicocele Management During Ipsilateral Inguinal Herniorrhaphy: A Prospective Study. Journal of the Chinese Medical Association 2010; 73(5):248-251 (SCI).

9.

Huang WJ, Lin YW, Hsiao KN, Eilbe KS, Salido EC, Yen PH. Restricted expression of the human DAZ protein in premeiotic germ cells. Human Reproduction 2009; 23:1280-1289 (SCI).

10.

Chen M, Huang YC, Ko IL, Yang S, Chang YH, Huang WJ, Chen YM.. The rs1447295 at 8q24 is a risk variant for prostate cancer in Taiwanese men. Urology 2009; 74(3):698-701 (SCI).

11.

Lin CC, Huang WJ, Chen KK. Measurement of testicular volume in smaller testes: how accurate is the conventional orchidometer? Journal of Andrology 2009; 30(6):685-689 (SCI).

12.

Huang WJ, Yen PH. Genetics of spermatogenic failure. Sexual Development 2008; 2:251-9 (SCI).

13.

Chen SS, Huang WJ, Chang LS, Wei YH. Attenuation of oxidative stress after varicocelectomy in subfertile patients with varicocele. Journal of Urology 2008; 179(2):639-42 (SCI).

14.

Lin CC, Huang WJ, Wu LJ, Chang YH, Lin AT, Chen KK.. Diagnosis of prostate cancer: repeated transrectal prostate biopsy or transurethral resection. Journal of the Chinese Medical Association 2008; 71(9):448-454 (SCI).

15.

Fan YH, Chang YH, Huang WJ, Chung HJ, Chen KK. Renal oncocytoma: clinical experience of Taipei Veterans General Hospital. Journal of the Chinese Medical Association 2008; 71(5):254-258 (SCI).

16.

Huang YC, Lee CM, Chen M, Chung MY, Chang YH, Huang WJ, Ho DM, Pan CC, Wu TT, Yang S, Lin MW, Hsieh JT, Chen YM.. Haplotypes, loss of heterozygosity, and expression levels of glycine N-methyltransferase in prostate cancer. Clinical Cancer Research 2007; 13(5):1412-20 (SCI).

17.

Huang WJ. ATP and spinal cord injury-related neurogenic bladder. Journal of the Chinese Medical Association 2007; 70(10):433-434 (SCI). (Impact factor:0.678; Rank:62.3%)

18.

Lin YH, Chung HJ, Lin AT, Chang YH, Huang WJ, Hsu YS, Chang SC, Chen KK. Complications of pure transperitoneal laparoscopic surgery in urology: the Taipei Veterans General Hospital experience. Journal of the Chinese Medical Association 2007; 70(11):481-485 (SCI).

19.

Tsai HW, Huang WJ, Chen CY, Chiang MM, Chao KC, Shen SH, Hung JH, Chen YJ. Two- and three-dimensional transvaginal Doppler ultrasound analysis of urethral clear cell carcinoma. Ultrasound in Obstetrics & Gynecology 2007; 29(6):713-716 (SCI).

20.

Huang YC, Chen M, Lin MW, Chung MY, Chang YH, Huang WJ, Wu TT, Hsu JM, Yang S, Chen YM.. CYP19 TCT tri-nucleotide Del/Del genotype is a susceptibility marker for prostate cancer in a Taiwanese population. Urology 2007; 69(5):996-1000 (SCI).

21.

Lin YW, Chia-Ling Hsu L, Kuo PL, Huang WJ, Chiang HS, Yeh SD, Hsu TY, Yu YH, Hsiao KN, Cantor RM, Yen PH. Partial duplication at AZFc on the Y chromosome is a risk factor for impaired spermatogenesis in Han Chinese in Taiwan. Human Mutation 2007; 28: (SCI).

22.

Chang YL, Lin AT, Chen KK, Chang YH, Wu HH, Kuo JY, Huang WJ, Lu SH, Hsu YS, Chung HJ, Chang SC.. Correlation between serum prostate specific antigen and prostate volume in Taiwanese men with biopsy proven benign prostatic hyperplasia. Journal of Urology 2006; 176:196-9 (SCI).

23.

Lin YH, Huang WJ, Chen KK. Using stainless steel chopstick for self-performing urethral sounding in preventing recurrence of anterior urethral stricture. Journal of the Chinese Medical Association 2006; 69:189-92 (SCI).

24.

Ng YY, Shen SH, Huang WJ. Chronic pyonephrosis with polycystic change. Nephrology 2005; 10:422-3 (SCI).

25.

Lin TP, Huang WJ, Chen KK. Differentiation of benign prostatic hyperplasia from prostate cancer using prostate specific antigen dynamic profile after transrectal prostate biopsy. Journal of Urology 2004; 171:2226-9 (SCI).

26.

Chen SS, Huang WJ, Chang LS, Wei YH. 8-Hydroxy-2'-deoxyguanosine in leukocyte DNA of spermatic vein as a biomarker of oxidative stress in patients with varicocele. Journal of Urology 2004; 172:1418-21 (SCI).

27.

Kan SF, Huang WJ, Lin LC, Wang PS. Inhibitory effects of evodiamine on the growth of human prostate cancer cell line LNCaP. International Journal of Cancer 2004; 110(5:641-51 (SCI).

28.

Lin TP, Pan CC, Huang WJ, Murphy GF. Primary sweat gland carcinosarcoma of the scrotal skin. Journal of Cutaneous Pathology 2004; 31(10):678-82 (SCI).

29.

Lin YM, Huang WJ, Lin JSN, Kuo PL. Progressive depletion of germ cells in a man with non-mosaic Klinefelter’s syndrome: optimal time for sperm recovery . Urology 2004; 63(2):380-1 (SCI).

30.

Tung MT, Huang WJ, Chen KK. Experiences of techiniques of a modifined subinguinal varicocelectomy for painful varicocele and varicocele-associated infertility. Journal of the Chinese Medical Association 2004; 67:296-300 (SCI).

31.

Sheu JY, Chung HJ, Chen KK, Lin AT, Chang YH, Wu HH, Huang WJ, Hsu YS, Kuo JY, Chang LS. Lymphangioma of male exogenital organs. Journal of the Chinese Medical Association 2004; 67:204-6 (SCI).

32.

Yang LY, Huang WJ, Hsieh HG, Lin CY. H1-A extracted from Cordyceps sinensis suppresses the proliferation of human mesangial cells and promotes apoptosis, probably by inhibiting the tyrosine phosphorylation of Bcl-2 and Bcl-XL. Journal of Laboratory and Clinical Medicine 2003; 141(1):74-83 (SCI).

33.

Hsu YS, Huang WJ, Kuo JY, Chung HJ, Chen KK, Chang LS. Experience of surgical treatment of Peyronie’s disease with deep dorsal venous patch graft in Taiwanese men. Journal of the Chinese Medical Association 2003; 66(8):487-491 (SCI).

34.

Sheu JY, Chen KK, Lin AT, Chang YH, Wu HH, Huang WJ, Hsu YS, Kuo JY, Chung HJ, Chang LS. Long-term efficacy and safety of sildenafil for patients with erectile dysfunction. Journal of the Chinese Medical Association 2003; 66(8):480-6 (SCI).

35.

Huang WJ, Yeh JY, Kan SF, Chang LS, Wang PS. Role of testicular interstitial macrophages in regulating testosterone release in hyperprolactinemia J Cell Biochem. Journal of Cellular Biochemistry 2003; 88(4):766-773 (SCI).

36.

Yeh JY, Huang WJ, Kan SF, Wang PS. Effects of bufalin and cinobufagin on the proliferation of androgen dependent and independent prostate cancer cells. Prostate 2003; 54(2):112-124 (SCI).

37.

Lin TP, Hsu YS, Chen KK, Lin AT, Chang YH, Wu HH, Huang WJ, Kuo JY, Chung HJ, Chang LS. Chyluria--experience of Taipei Veterans General Hospital. Journal of the Chinese Medical Association 2003; 66(2):109-112 (SCI).

38.

Lin AD, Chen KK, Lin AT, Chang YH, Wu HH, Kuo JY, Huang WJ, Hsu YS, Chung HJ, Chang LS. Antiandrogen-associated hepatotoxicity in the management of advanced prostate cancer. Journal of the Chinese Medical Association 2003 Dec; 66(12):735-40 (SCI).

39.

Yang MH, Chen KK, Yen CC, Wang WS, Chang YH, Huang WJ, Fan FS, Chiou TJ, Liu JH, Chen PM H. Unusually high incidence of upper urinary tract urothelial carcinoma in Taiwan Urology. Urology 2002; 59:681-687 (SCI).

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Research grant: 

2010/08/01~2011/07/31

The effects of prolactin and TNF-α峱n male reproductive function, germ cell apoptosis and autophagy

National Science Council

 

2010/08/01~2011/07/31

Characterizing of germ cells on testis tissue smear at different differentiation, the application in micro testicular sperm extraction

National Science Council

 

 

2009/08/01~2010/07/31

Characterizing of germ cells on testis tissue smear at different differentiation, the application in micro testicular sperm extraction

National Science Council

2007/08/01~2008/07/31

Germ cell apoptosis and its regulation by follicle stimulating

National Science Council

2007/08/01~2008/08/31

DAZ gene functional analysis

National Science Council

2011/01/01~2011/12/31

Integrated clinical faculty development program of department of surgery

Taipei VGH

 

2011/01/01~2011/12/31

The reproductive function of hyperprolactinemic male rats-part 2

Taipei VGH

2011/01/01~2011/12/31

Integrated Clinical Teacher Training Program of Department of Surgery

Taipei VGH

2010/01/01~2010/12/31

Promotion project of evidence-based teaching and research

Taipei VGH

2010/01/01~2010/12/31

The reproductive function of hyperprolactinemic male rats

Taipei VGH

2010/01/01~2010/12/31

Integrated Clinical Teacher Training Program of Department of Surgery

Taipei VGH

2009/01/01~2009/12/31

The relationship of TNF-alpha and induction of apoptosis of spermatogonia in hyperprolactinemic rats

Taipei VGH

2009/01/01~2009/12/31

Clinical surgical teacher training program and efficacy assessment

Taipei VGH

2008/01/01~2008/12/31

Assessment of clinical teaching in urology

Taipei VGH

2008/01/01~2008/12/31

The study of mechanism to induce apoptosis of germ cell in male hyperprolactinemic rats

Taipei VGH

2008/01/01~2008/12/31

Ethnic Variation in Intratesticular Testosterone

Taipei VGH

2007/01/01~2007/12/31

Faculty development program of Urology

Taipei VGH

2007/01/01~2007/12/31

The effect of testicular macrophage on spermatogenesis

Taipei VGH

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Lab membership:

Master Student: 

Ph.D. Student: Zhong-Lin Wang 

Research Assistant: Yu-Chi Chen, Hsin Lee, Shih-Fang Huang 

Post Doctoral Fellows: Yi-Te Chiang

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