National Yang-Ming University, Department & Institute of Physiology

National Yang-Ming University, Department & Institute of Physiology

Low-Tone Ho

 Research Field    Publications    Research grant    Lab intro    (2010.11.24  update)

Name Low-Tone Ho  Low-Tone Ho

Adjunct Professor

Tel. 886-2-2875-7156
Fax No. 886-2-2826-4049


1984 MD National defense medical center medicine



B.S. National defense medical center medicine


Doctor researcher in the University of Michigan


Director of the department of internal medicine metabolism branch endocrine function rooms in Taipei veterans general hospital


Adjunct professor in National defense medical center and Yang-Ming University


Director of the department of internal medicine metabolism branch in Taipei veterans general hospital


Adjunct professor in National defense medical center , Yang-Ming University and national Tsing Hua university

1994-now Director of the Teaching and Research Department in Taipei veterans general hospital
1999-2005 Dr. metabolism branch
Dean of the Medical School in YM


Research Interests:

Hypertension, abnormal glucose tolerance, obesity, hypertriglyceridemia, low high-density cholesterol disease, often combined with hyperinsulinemia and insulin resistance phenomenon, this group always portfolio increased atherosclerosis and coronary heart disease incidence and mortality. Engaged in the research and type 2 diabetes that is non-insulin-dependent diabetes mellitus (Non-Insulin Dependent Diabetes Mellitus, NIDDM) related to basic and clinical research, mainly on endothelin-1 (Endothelin-1) in the hypertensive patients with insulin resistance pathogenesis of the role played by. Study results include:

(1) Endothelin-1 inhibited rat insulin on fat cells by promoting a glucose transport in vitro, and this inhibition is primarily through the endothelin A receptor

(2) Endothelin-1 in vivo perfusion cause of insulin resistance in rats

(3) Feeding fructose-induced hypertension in rats, the tail artery in the endothelin-1 and A-type receptor gene expression have increased significantly phenomenon

(4) Island-impedance of the rats, their fat cells Resistin gene expression suppress the case. Current research focuses on the development of genetic epidemiology of diabetes clinical research, endothelin-1 in insulin signal impedance of the transmission mechanism of fat cell hormone and insulin resistance related to the relevance, and endothelin antagonist of the relevant role - to its prevention and treatment. Ji its combination of genetic epidemiology, the health, physiology, pharmacology and the multiple discussion on hypertension associated with insulin resistance for a more in-depth understanding.


Selected Recent Publications:


1.   Seow KM, Juan CC, Hsu YP, Ho LT, Wang YY, Hwang JL. Serum and follicular resistin levels in women with polycystic ovarian syndrome during IVF-stimulated cycles. Hum Reprod 2005; 20(1):117-121.

2.   Huang SW, Seow KM, Ho LT, Chien Y, Chung DY, Chang CL, Lai YH, Hwang JL, Juan CC. Resistin mRNA levels are downregulated by estrogen in vivo and in vitro. FEBS Lett 2005; 579(2):449-454.

3.   Lee TS, Chao T, Tang RB, Hsieh CC, Chen SJ, Ho LT. A longitudinal study of growth patterns in schoolchildren in one Taipei district II: sitting height, arm span, body mass index, and skinfold thickness. J Chin Med Assoc 2005; 68(1):16-20.

4.   Chen YJ, Shieh CJ, Tsai TH, Kuo CD, Ho LT, Liu TY, Liao HF. Inhibitory effect of norcantharidin, a derivative compound from blister beetles, on tumor invasion and metastasis in CT26 colorectal adenocarcinoma cells. Anticancer drugs 2005; 16:293-299.  

5.   Kwok CF, Juan CC, Shih KC, Hwu CM, Jap TS, Ho LT. Insulin-like growth factor-1 increases endothelin receptor A levels and action in cultured rat aortic smooth muscle cells. J Cell Biochem 2005; 94(6):1126-1134.

6.   Lin YY, Chen WT, Liao KK, Yeh TC, Wu ZA, Ho LT. Hemispheric balance in coding speech and non-speech sounds in Chinese participants.  Neuroreport 2005; 16(5):469-473.

7.   Lin YY, Chen WT, Liao KK, Yeh TC, Wu ZA, Ho LT, Lee LS. Differential generators for N20m and P35m responses to median nerve stimulation. Neuroimage 2005; 25:1090-1099.

8.   Chen WT, Ko YC, Liao KK, Hsieh JC, Yeh TC, Wu ZA, Ho LT, Lin YY. Optimal check size and reversal rate to elicit pattern-reversal MEG responses. Can J Neurol Sci. 2005; 32(2):218- 224.

9.   Juan CC, Chien Y, Wu LY, Yang WM, Chang CL, Lai YH, Ho PH, Kwok CF, Ho LT. Angiotensin II enhances insulin sensitivity in vitro and in vivo. Endocrinology 2005; 146(5):2246-2254.

10. Juan CC, Chang CL, Lai YH, Ho LT. Endothelin-1 induces lipolysis in 3T3-L1 adipocytes.
Am J Physiol Endocrinol Metab 2005; 288(6):E1146-1152.

11. Chang AY, Wang CH, Chiu TH, Chi JW, Chen CF, Ho LT, Lin AM. Hypoxic preconditioning attenuated in kainic acid-induced neruotoxicity in rat hippocampus. Exp Neurol 2005; 195(1): 40-48.

12. Chen SM, Kuo CD, Liao JF, Ho LT. Effects of parathyroid hormone on plasma zinc concentration in rat with chronic renal failure. Chin J Physiol 2005; 48(3):121-128.

13. Lin LY, Kwok CF, Tang KT, Ho LT, Lin HD. Diffuse soft tissue emphysema in anorexia nervosa: a case report. Int J Eat Disord 2005; 38(3):277-280.

14. Chen SM, Kuo CD, Ho LT, Liao JF. Effect of Hypothyroidism on Intestinal Zinc Absorption and Renal Zinc Disposal in Five-Sixths Nephrectomized Rats. Jpn J Physiol 2005; 55(4): 211-219.

15. Chao HT, Kuo CD, Su YJ, Chuang SS, Fang YJ, Ho LT. Short-term effect of transdermal estrogen on autonomic nervous modulation in postmenopausal women. Fertil Steril 2005; 84(5):1477-1483.

16. Hung CJ, Huang PC, Li YH, Lu SC, Ho LT, Chou HF.  Taiwanese vegetarians have higher insulin sensitivity than omnivores. Br J Nutr 2006; 95(1):129-135.

17. Wang WC, Chang IS, Chang CH, Curb D, Ho LT, Hsiung CA. Incorporating endophenotypes into allele-sharing based linkage tests. Genet Epidemiol 2006; 30(2):133-142.

18. Lee YC, Ko YH, Hsu YP, Ho LT. Plasma leptin response to oral glucose tolerance and fasting/re-feeding tests in rats with fructose-induced metabolic derangements. Life Sciences 2006; 78:1155-1162.

19. Liou TL, Lin MW, Hsiao LC, Tsai TT, Chan WL, Ho LT, Hwu CM. Is hyperuricemia another facet of the metabolic syndrome?  J Chin Med Assoc 2006; 69(3):104-109.

20.  Hsiao FJ, Lin YY, Hsieh JC, Wu ZA, Ho LT, Chang Y. Oscillatory characteristics of face-evoked neuromagnetic responses. Int J Psychophysiol 2006 (in press).

21. Chen WT, Yuan RY, Shih YH, Yeh TC, Hung DL, Wu ZA, Ho LT, Lin YY. Neuromagnetic SII responses do not fully reflect pain scale. Neuroimage. 2006(in press).

22. Lin YY, Hsiao FJ, Chang KP, Wu ZA, Ho LT. Bilateral oscillations for lateralized in benign rolandic epilepsy. Epilepsy Res 2006; 69: 45-52.

23. Chiou SH, Chen SJ, Peng CH, Chang YL, Ku HH, Hsu WM, Ho LT, Lee CH. Fluoxetin up-regulates expression of cellular FLICE-inhibitory protein and inhibits LOS-induced apoptosis in hippocampus-derived neural stem cell. Biochem Biophys Res Commun 2006; 343:391-400.

24. Juan CC, Chang LW, Huang SW, Chang CL, Lee CC, Chien Y, Hsu YP, Ho PH, Chen YC, Ho LT. Effects of endothelin-1 on lipolysis in rat adipocytes. Obesity 2006; 14:398-404. 

25. Chiou SH, Ku HH, Tsai TH, Lin HL, Chen LH, Chien CS, Ho LT, Lee CH, Chang YL. Moclobemide upregulated Bcl-2 expression and induced neural stem cell differentiation into serotoninergic neuron via extracellular-regulated kinase pathway. Br J Pharmacol 2006; 148:587-598.

26. Lin HT, Chiou SH, Kao CL, Shyr YM, Hsu CJ, Tarng YW, Ho LT, Kwok CF, Ku HH. Characterization of pancreatic stem cells derived from adult human pancreas ducts by fluorescence activated cell sorting.  World J Gastroenterol 2006; 12:4529-4535.

27. Lin YY, Liao KK, Chen JT, Yeh TC, Shih YH, Wu ZA, Ho LT. Neural correlates of Chinese word-appropriateness judgment: an MEG study. Int J Psychophysiol 2006; 62: 122-133.

28. Wu YZ, Yang TH, Lin YY, Chen SS, Liao KK, Chen LF, Yeh TC, Wu YT, Ho LT, Hsieh JC. Dimensional complexity of neuromagnetic activity reduced during finger movement of greater difficulty. Clin Neurophysiol 2006; 117:2473-2481.

29. Lin MW, Hwu CM, Huang YH, Sheu WH, Shih KC, Chiang FT, Olshen R, Chen YD, Curb JD, Rodriguez B, Ho LT: SAPPHIRe study group. Directly measured insulin resistance and the assessment of clustered cardiovascular risks in hypertension. Am J Hypertens 2006; 19:1118-1124.


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