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National Yang-Ming University, Department & Institute of Physiology
National Yang-Ming University, Department & Institute of Physiology
Yuh-Lin Wu

 Research Field    Publications    Research grant    Lab intro    (2015.07.06 update)

 

Name

Yuh-Lin Wu 

 

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Position

Professor

Tel. 886-2-2826-7081
Fax No. 886-2-2826-4049
E-mail

ylwu@ym.edu.tw

Education
2001 PhD Endocrinology- Reproductive-Physiology, University of Wisconsin-Madison  
1992 MS Microbiology, National Taiwan University  
1990 BS Biology, National Cheng Kung University 
Experience

Compulsory Military Service in Army (7/1992 - 6/1994)

As a second lieutenant arranging the medical missions and military training

Teaching Assistant (8/1994 - 7/1995) Institute of Microbiology, College of Medicine, National Taiwan University.

Teaching Assistant (1/2000 - 5/2000) Department of Animal Sciences, University of Wisconsin-Madison.

Postdoctoral Research (9/2001 - 7/2004) Department of Biochemistry and Biophysics, University of North Carolina-Chapel Hill.

Assistant Professor (8/2004 - 1/2010) Department  and Institute of Physiology, School of Medicine, National Yang-Ming University.

Assistant Professor (2/2010 - 1/2017) Department  and Institute of Physiology, School of Medicine, National Yang-Ming University.

Professor (2/2017 - Present) Department  and Institute of Physiology, School of Medicine, National Yang-Ming University.

Research Interests:
Lab Interests:

 Molecular Endocrinology: Adopt current protocols to study endocrine functions as well as signal transduction  mechanisms:

1. G protein signaling in ovarian system and cellular differentiation process

2. Roles of RGS proteins in inflammation

3. Significance of novel anti-inflammatory molecules in physiology and cancer progression  

4. Significance of glucosamine in physiology 

 Currently our team includes one research assistant, two undergraduates, and five graduate students.

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Selected Recent Publications:
1 Yeh HY, Sun D, Peng YC, Wu YL*. Regulation of the regulator of G protein signaling 2  expression and cellular localization by PKA and PKC pathways in mouse granulosa cells. Biochemical and Biophysical Research Communications 2018 (Jun 20. pii: S0006-291X(18)31413-X. doi: 10.1016/j.bbrc.2018.06.101. [Epub ahead of print] (*Correspondence) 
2 Chen HT, Sun D, Peng YC, Kao PH, Wu YL*. Novel augmentation by bufalin of protein kinase C-induced cyclooxygenase-2 and interleukin-8 production in human breast cancer cells. Innate Immunity  2017;23:54-66 (*Correspondence)
3 Chao YN, Sun D, Peng YC, Wu YL*. Growth hormone releasing peptide-2 attenuation of protein kinase C-induced inflammation in human ovarian granulosa cells. International Journal of Molecular Sciences 2016 Aug 19;17(8). pii: E1359. doi: 10.3390/ijms17081359 (*Correspondence)
4 Ou HL, Sun D, Peng YC, Wu YL*. Novel effects of the cyclooxygenase-2-selective inhibitor NS-398 on IL-1b-induced cyclooxygenase-2 and IL-8 expression in human ovarian granulosa cells. Innate Immunity  2016; 22:452-465. (*Correspondence)
5 Peng YC, Lin CL, Yeh HZ, Chang CS, Wu YL, Kao CH. Association Between the Use of Proton Pump Inhibitors and the Risk of ESRD in Renal Diseases: A Population-Based, Case-Control Study. Medicine (Baltimore) 2016 Apr;95(15):e3363. doi: 10.1097/MD.0000000000003363.
6 Peng YC, Lin CL, Hsu WY, Chang CS, Yeh HZ, Tung CF, Wu YL, Sung FC, Kao CH. Statins are associated with a reduced risk of Cholangiocarcinoma: a population-based case-control study. Br J Clin Pharmacol. 2015;80:755-761
7 Chou WY, Chuang KH, Sun D, Lee YH, Kao PH, Lin YY, Wang HW, Wu YL*. Inhibition of PKC-induced COX-2 and IL-8 Expression in Human Breast Cancer Cells by Glucosamine. J Cell Physiol. 2015;230:2240-2251
8 Chien HY, Lu CS, Chuang KH, Kao PH, Wu YL*. Attenuation of lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression by lysophosphatidic acid in macrophages. Innate Immun. 2015;21:635-646.
9 Wu YL. Lin AH, Chen CH, Huang WC, Wang HY, Liu MH, Lee TS, Kou YR. Glucosamine attenuates cigarette smoke-induced lung inflammation by inhibiting ROS-sensitive inflammatory signaling. Free Radic Biol Med. 2014;69:208-218.
10 Chuang KH, Peng YC, Chien HY, Lu ML, Du HI, Wu YL*. Attenuation of Lipopolysaccharide-induced Lung Inflammation by Glucosamine in Rats. Am J Respir Cell Mol Biol. 2013 49:1110-1119. (*Correspondence)
11 Chuang KH, Lu CS, Kou YR, Wu YL*. Cell Cycle Regulation by Glucosamine in Human Pulmonary Epithelial Cells. Pulmonary Pharmacology and Therapeutics 2013;26:195-204. (*Correspondence)
12 Salim S, Asghar M, Taneja M, Hovatta I, Wu YL, Saha K, Sarraj N, Hite B. Novel role of RGS2 in regulation of antioxidant homeostasis in neuronal cells. FEBS Lett 2011;585:1375-1381.
13 Tang GJ, Wang HY, Wang JY, Lee CC, Tseng HW, Wu YL, Shyue SK, Lee TS, Kou YR. Novel role of AMP-activated protein kinase signaling in cigarette smoke induction of IL-8 in human lung epithelial cells and lung inflammation in mice. Free Radic Biol Med 2011;50:1492-502.
14 Chen CY, Shyue SK, Ching LC, Su KH, Wu YL, Kou YR, Chiang AN, Pan CC, Lee TS. Wogonin promotes cholesterol efflux by increasing protein phosphatase 2B-dependent dephosphorylation at ATP-binding cassette transporter-A1 in macrophages. J Nutr Biochem 2011;22:1015-1021. [Epub ahead of print]
15
Cheng LC, Su KH, Kou YR, Shyue SK, Ching LC, Yu YB, Wu YL, Pan CC, Lee TS. α-Lipoic acid ameliorates foam cell formation via liver X receptor α-dependent upregulation of ATP-binding cassette transporters A1 and G1. Free Radical Biology and Medicine 2011;50:47-54.
16 Wu YL*, Kou YR, Ou HL, Chien HY, Chuang KH, Liu HH, Lee TS, Tsai CY, Lu ML. Glucosamine Regulation of LPS-mediated Inflammation in Human Bronchial Epithelial Cells. European Journal of Pharmacology 2010;635:219-226. (*Correspondence)
17 Chen CY, Shyue SK, Ching LC, Su KH, Wu YL, Kou YR, Chiang AN, Pan CC, Lee TS. Wogonin promotes cholesterol efflux by increasing protein phosphatase 2B-dependent dephosphorylation at ATP-binding cassette transporter-A1 in macrophages. J Nutritional Biochemistry 2011;22:1015-1021.
18 Cheng LC, Su KH, Kou YR, Shyue SK, Ching LC, Yu YB, Wu YL, Pan CC, Lee TS. α-Lipoic acid ameliorates foam cell formation via liver X receptor α-dependent upregulation of ATP-binding cassette transporters A1 and G1. Free Radical Biology and Medicine 2011;50:47-54.
19 Tsai JY, Su KH, Shyue SK, Kou YR, Yu YB, Hsiao SH, Chiang AN, Wu YL, Ching LC, Lee TS. EGb761 ameliorates the formation of foam cells by regulating the expression of SR-A and ABCA1: role of haem oxygenase-1. Cardiovasc Res 2010;88:415-423.
20 Tsai CY, Lee TS, Kou YR, Wu YL*. Glucosamine Inhibits IL-1b-mediated IL-8 Production in Prostate Cancer Cells by MAPK Attenuation. Journal of Cellular Biochemistry 2009; 108:489-498. (*Correspondence)
21 Hsu CL, Wu YL, Tang GJ, Lee TS, Kou YR. Ginkgo Biloba Extract Confers Protection from Cigarette Smoke Extract-induced Apoptosis in Human Lung Endothelial Cells: Role of Heme Oxygenase-1. Pulmonary Pharmacology and Therapeutics 2009; 22:286-296.
22 Su KH, Tsai JY, Kou YR, Chang AN, Hsiao SH, Wu YL, Hou HH, Pan CC, Shyue SK, Lee TS. Valsartan Regulates the Interaction of Angiotensin II Type 1 Receptor and Endothelial Nitric Oxide Synthase via Src/PI3K/Akt Signaling. Cardiovascular Research 2009; 82:468-475.
23 Lee TS, Lin CY, Tsai JY, Wu YL, Su KH, Lu KY, Hsiao SH, Pan CC, Kou YR, Hsu YP, Ho LT. Resistin Increases Lipid Accumulation byAffecting Class A Scavenger Receptor, CD36 and ATP-binding Cassette Transporter-A1 in Macrophages. Life Sciences 2009; 84:97-104.
24 Cheng YS, Lee TS, Hsu HC, Kou YR, Wu YL*. Characterization of the Transcriptional Regulation of the Regulator of G Protein Signaling 2 (RGS2) Gene during 3T3-L1 Preadipocyte Differentiation. Journal of Cellular Biochemistry 2008; 105:922-930. (*Correspondence)
25 Lee TS, Liu YJ, Tang GJ, Yien HW, Wu YL, Kou YR.Wood Smoke Extract Promotes both Apoptosis and Proliferation in Rat Alveolar Epithelial Type II Cells: the Role of Oxidative Stress and Heme Oxygenase-1. Critical Care of Medicine 2008; 36:2597-2606.
26 Wu YL*, Chuang HH, Kou YR, Lee TS, Lu SH, Huang YC, Nishi Y, Yanase T. Regulation of LH Receptor and PGF2Receptor Signaling by the Regulator of G Protein Signaling 2 (RGS2) in Human and Mouse Granulosa Cells. Chinese Journal of Physiology 2008; 51:282-291.(*Correspondence)
27 Yang YL, Tang GJ, Wu YL, Yien HW, Lee TS, Kou YR. Exacerbation of Wood Smoke-induced Acute Lung Injury by Mechanical Ventilation Using Moderately High Tidal Volume in Mice. Respiratory Physiology & Neurobiology 2008; 160:99-108.

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