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National Yang-Ming University, Department & Institute of Physiology
National Yang-Ming University, Department & Institute of Physiology
Chi-Chang Juan

 Research Field    Publications    Research grant    Lab intro    (2010.11.24  update)


Chi-Chang Juan

Position Professor
Tel. 886-2-2826-7082
Fax No. 886-2-2826-4049




Physiology, National Yang-Ming University, Taipei, Taiwan



Physiology, National Yang-Ming University, Taipei, Taiwan



Biology, Tung-hai University, Taichung, Taiwan


Postdoctoral Fellow, Department of Medical Research & Education, Taipei Veterans General Hospital, Taipei, Taiwan.

Research Interests:

My major research interests are (1) pathogenic mechanism of metabolic syndrome, (2) metabolic effects of vasoactive hormones, (3) expression of recombinant protein, (4) role of adipocytokines in the pathological pathway of obesity and insulin resistance.  Research approaches employ the techniques of cell physiology, endocrinology, biochemistry and molecular biology.


Selected Recent Publications:
Research grant:
01 Chen JY, Jian DY, Lien CC, Lin YT, Ting CH, Chen LK, Hsu TC, Huang HM, Wu YT, Kuan TT, Chao YW, Wu LY, Huang SW, Juan CC*. Adipocytes play an etiological role in the podocytopathy of high-fat diet-fed rats. J Endocrinol. 231: 109-120, 2016.
02 Huang YH, Jian DY, Lien CC, Juan CC*. Short-Term Hypoxia-Induced Inhibition of Adipogenesis and Enhancement of Insulin Sensitivity in 3T3-L1 Adipocytes Adaptive Medicine 8: 12-23, 2016.
03 Lin YT, Jian DY, Kwok CF, Ho LT, Juan CC*. Visfatin Promotes Foam Cell Formation by Dysregulating Cd36, Sra, Abca1 and Abcg1 Expression in Raw264.7 Macrophages. Shock. 45: 460-468, 2016.
04 Lien cc, Jiang JL, Jian DY, Kwok CF, Ho LT, Juan CC*. Chronic endothelin-1 infusion causes adipocyte hyperplasia in rats. Obesity. 24: 643-53, 2016.
05 How CK, Hou SK, Chen LK, Yang CM, Huang HH, Shih HC, Huang MS, Chiou SH, Lee CH, Juan CC*. Induced pluripotent stem cells alleviate lung injury from mesenteric ischemia-reperfusion. J Trauma Acute Care Surg. 79: 592-601, 2015.
06 Chang CJ, Jian DY, Lin MW, Zhao JZ, Ho LT, Juan CC*. Evidence in Obese Children: Greater Contribution of Hyperlipidemia than Those of Obesity-Inflammation and Insulin Sensitivity. PLoS One. 10: e0125935, 2015.
07 Juan CC, Chen KH, Wang PH, Hwang JL, Seow KM. Endocannabinoid system activation might be associated to insulin resistance in women with polycystic ovary syndrome. Fertil Steril. 104: 200-206, 2015.
08 Lin YJ, Juan CC, Kwok CF, Hsu YP, Shih KC, Chen CC, Ho LT. Endothelin-1 exacerbates development of hypertension and atherosclerosis in modest insulin resistant syndrome. Biochem Biophys Res Commun. 460: 497-503, 2015.
09 How CK, Hou SK, Shih HC, Huang MS, Chiou SH, Lee CH, Juan CC*. Expression profile of MicroRNAs in gram-negative bacterial sepsis. Shock. 43: 121-127, 2015.
10 Wei TY, Hsia JY, Chiu SC, Su LJ, Juan CC (Co-first author), Lee YC, Chen JM, Chou HY, Huang JY, Huang HM, Yu CT. Methylosome protein 50 promotes androgen- and estrogen-independent tumorigenesis. Cell Signal. 26: 2940-2950, 2014.
11 Lin YJ, Kwok CF, Juan CC, Hsu YP, Shih KC, Chen CC, Ho LT. Angiotensin II enhances endothelin-1-induced vasoconstriction through upregulating endothelin type A receptor. Biochem Biophys Res Commun. 451: 263-269, 2014.
12 Tang YC, Liu CW, Chang HH, Juan CC, Kuo YC, Kao CC, Huang YM, Kao YH. Endothelin-1 stimulates resistin gene expression. Endocrinology. 155: 854-864, 2014.
13 Chuang TY, Chang FY, Juan CC, Wang PS. Adaptive Roles of Adiponectin and Resistin in Cardiovascular Diseases. Adaptive Medicine 5: 21-28, 2013.
14 Ho LT, Hsu YP, Hsiao CF, Ting CT, Shih KC, Chuang LM, Masaki K, Grove J, Quertermous T, Juan CC, Lin MW, Chiang SC, Chen YD. Endothelin Type A Receptor Genotype is a Determinant of Quantitative Traits of Metabolic Syndrome in Asian Hypertensive Families: A SAPPHIRe Study. Front Endocrinol (Lausanne). 4:172, 2013.
15 Jian DY, Chao YW, Ting CH, Huang SW, Chang CF, Juan CC*, Chen JY. Losartan ameliorates renal injury, hypertension, and adipocytokine imbalance in 5/6 nephrectomized rats. Eur J Pharmacol.709:85-92, 2013.
16  Seow KM, Lin YH, Wang PH, Hwang JL, Ho LT,Juan CC*. Aquaglyceroporin-7 overexpression in women with the polycystic ovary syndrome. Gynecol Obstet Invest. 75: 126-131, 2013.
17 How CK, Chien Y, Yang KY, Shih HC, Juan CC, Yang YP, Chiou GY, Huang PI, Chang YL, Chen LK, Wang CY, Hsu HS, Chiou SH, Lee CH. Induced pluripotent stem cells mediate the release of interferon gamma-induced protein 10 and alleviate bleomycin-induced lung inflammation and fibrosis. Shock. 39: 261-270, 2013.
18 Seow KM, Lee JL, Doong ML, Huang SW, Hwang JL, Huang WJ, Chang FY, Ho LT, Juan CC*.  Human chorionic gonadotropin regulates gastric emptying in ovariectomized rats. J Endocrinol. 216: 307-314, 2013.
19 Chen CY, Ho LT, Yang FY, Juan CC*. Au LC. Prunellae Spica extract contains antagonists for human endothelin receptors. Am J Chin Med. 41: 85-98, 2013.
20 Liu TY, Chen CY, Juan CC*. , Au LC. Coding region of adiponectin contains a silent intron reactivated by the adjacent intervening sequence of vector. Plasmid. 69(1):67-71, 2013.
21 Wei TY, Juan CC (Co-first author), Hisa JY, Su LJ, Lee YC, Chou HY, Chen JM, Wu YC, Chiu SC, Hsu CP, Liu KL, Yu CT. Protein arginine methyltransferase 5 is a potential oncoprotein that upregulates G1 cyclins/cyclin-dependent kinases and the phosphoinositide 3-kinase/AKT signaling cascade. Cancer Sci. 103: 1640-1650, 2012.
22 Seow KM, Juan CC, Wang PH, Ho LT, Hwang JL. Expression levels of vascular cell adhesion molecule-1 in young and nonobese women with polycystic ovary syndrome. Gynecol Obstet Invest. 73: 236-241, 2012.
23 Chai SP, Juan CC, Kao PH, Wang DH, Fong JC. Synergistic induction of interleukin-6 expression by endothelin-1 and cyclic AMP in adipocytes. Int J Obes (Lond). 37: 197-203, 2013.
24 Seow KM, Hwang JL, Wang PH, Ho LT, Juan CC*.  Expression of visfatin mRNA in peripheral blood mononuclear cells is not correlated with visfatin mRNA in omental adipose tissue in women with polycystic ovary syndrome. Hum Reprod. 26: 2869-2873, 2011.
25 Chuang TY, Au LC, Wang LC, Ho LT, Yang DM, Juan CC*.Potential effect of resistin on the ET-1-increased reactions of blood pressure in rats and Ca2+ signaling in vascular smooth muscle cells. J Cell Physiol. 227: 1610-1618, 2012.
26 Huang PI, Chen YC, Chen LH, Juan CC, Ku HH, Wang ST, Chiou SH, Chiou GY, Chi CW, Hsu CC, Lee HC, Chen LK, Kao CL. PGC-1α mediates differentiation of mesenchymal stem cells to brown adipose cells. J Atheroscler Thromb. 18: 966-980, 2011.
27 Hsu WY, Chao YW, Tsai YL, Lien CC, Chang CF, Deng MC, Ho LT, Kwok CF, Juan CC*. Resistin induces monocyte-endothelial cell adhesion by increasing ICAM-1 and VCAM-1 expression in endothelial cells via p38MAPK-dependent pathway. J Cell Physiol. 226: 2181-2188, 2011.
28 Seow KM, Lin YH, Hwang JL, Wang PH, Ho LT, Lin YH, Juan CC*.  Expression levels of haem oxygenase-1 in the omental adipose tissue and peripheral blood mononuclear cells of women with polycystic ovary syndrome. Hum Reprod. 26: 431-437, 2011.
29 Chang CL, Au LC, Huang SW, Fai Kwok C, Ho LT, Juan CC*. Insulin up-regulates heme oxygenase-1 expression in 3T3-L1 adipocytes via PI3-kinase- and PKC-dependent pathways and heme oxygenase-1-associated microRNA downregulation. Endocrinology. 152: 384-393, 2011.
30 Seow KM, Tsai YL, Juan CC, Huang LW, Hwang JL, Ho LT. Omental fat receptor interacting protein 140 mRNA expression in women with polycystic ovary syndrome. Gynecol Obstet Invest. 69: 51-56, 2010.
31 Seow KM, Tsai YL, Juan CC, Lin YH, Hwang JL, Ho LT. Omental fat expression of adiponectin and adiponectin receptors in non-obese women with PCOS: a preliminary study. Reprod Biomed Online. 19: 577-82, 2009.
32 Lien CC, Au LC, Tsai YL, Ho LT,  Juan CC*.  Short-term regulation of tumor necrosis factor-alpha-induced lipolysis in 3T3-L1 adipocytes is mediated through the inducible nitric oxide synthase/nitric oxide-dependent pathway. Endocrinology. 150: 4892-4900, 2009.
33 Seow KM, Tsai YL, Hwang JL, Hsu WY, Ho LT,  Juan CC*. Omental adipose tissue overexpression of fatty acid transporter CD36 and decreased expression of hormone-sensitive lipase in insulin-resistant women with polycystic ovary syndrome. Hum Reprod. 24: 1982-1988, 2009.
34 Chen HS, Wu TE, Juan CC, Lin HD. Myocardial heat shock protein 60 expression in insulin-resistant and diabetic rats. J Endocrinol. 200:151-157, 2009.
35  Juan CC, Au LC, Yang FY, Yang DM, Ho LT. An endothelin type A receptor-expressing cell to characterize endothelin-1 binding and screen antagonist. Anal Biochem. 379: 27-31, 2008.
36 Juan CC*, Lien CC, Chang CL, Huang YH, Ho LT. Involvement of iNOS and NO in TNF-alpha-downregulated Resistin Gene Expression in 3T3-L1 Adipocytes. Obesity (Silver Spring). 16: 1219-1225, 2008. 
37 Seow KM, Juan CC, Hwang JL, Ho LT. Laparoscopic surgery in polycystic ovary syndrome: reproductive and metabolic effects. Semin Reprod Med. 26: 101-110, 2008.
38 Juan CC*. , Chuang TY, Lien CC, Lin YJ, Huang SW, Kwok CF, Ho LT. Leptin increases endothelin type A receptor levels in vascular smooth muscle cells. Am J Physiol Endocrinol Metab. 294: E481-E487, 2008.


Corresponding author.

Lab membership:

Master Student: Ting-Chia Hsu, Tai-Ying Huang, Shuan-Ming Huang, shao-Yun Wu, Ze-Ting Guan

Ph.D. Student: Chih-Chan Lien, Yu-Ting Lin, Lun-Quen Chen

Research Assistant:

Post Doctoral Fellows:






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