Your browser does not support JavaScript!
National Yang-Ming University, Department & Institute of Physiology
National Yang-Ming University, Department & Institute of Physiology
Paulus Shyi-Gang Wang

 Research Field    Publications    Research grant    Lab intro    (2014.09.23  update)

Name Shyi-Gang Wang (also Known as Paulus S. Wang)  

Position Adjunct Professor
Tel. 886-2-2826-7082
Fax No. 886-2-2826-4049



Department of Veterinary Biosciences University of Illinois at Champaign-Urbana, Illinois, U.S.A.



Department of Zoology, National Taiwan University, Taipei, Taiwan, R.O.C.



Department of Zoology, National Taiwan University, Taipei, Taiwan, R.O.C.



Assistant Research Fellow, Institute of Zoology, Academia,

Sinica, Taipei, Taiwan, R.O.C.


Associate Professor, Department of Physiology, National Yang-Ming Medical College, Taipei, Taiwan, R.O. C.


Fogarty International Fellow, Department of Obstetrics and Gynecology,

The University of Texas Health Science Center at Dallas, Dallas, Texas, U.S.A.


Chairman, Department and Institute of Physiology,

National Yang-Ming Medical College, Taipei, Taiwan, R.O.C.


Professor, Department and Institute of Physiology,

National Yang-Ming Medical College, Taipei, Taiwan, R.O.C.


Professor, Department and Institute of Physiology,

National Yang-Ming University, Taipei, Taiwan, R.O.C.


Vice-Dean, School of Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C


Director, Laboratory Animal Center,

National Yang-Ming University, Taipei, Taiwan, R.O.C.


Director, Ph. D. Program for Aging, College of Medicine, China Medical University,

Taichung, Taiwan, R.O.C.


Director, Medical Center for Aging, China Medical University,

Taichung, Taiwan, R.O.C.

Research Interests:

My major research interests are (1) the pharmacological and toxic effects of clinical and Chinese medicines on the steroidogenesis in cells of adrenal cortex and gonads, (2) the effects of clinical and Chinese medicines on the proliferation and cell cycles in human prostate cancer cells, and (3) the hormonal regulation of gastric emptying and intestinal transit in rats. The concentration of both steroid and peptide hormones are determined by radioimmunoassay. Western blot and RT-PCR technologies are employed to examine protein expression and gene expression, respectively. We provide both master and Ph. D. program for graduate students, and collaborate with several physicians in the Divisions of Gastroenterology and Urology in Taipei-Veterans General Hospital.

Selected Recent Publications:
1 Yu, P.L., Lin, T.M., Wang, S.W.*, and Wang, P.S.* Antisteroidogenic effects of hydrogen peroxide on rat granulosa cells. Free Radical Res. 46:718-725, 2012. (* Equal Contributions)
2 Chang, L.L. and Wang P.S.* Effects of vitamin E on steroidogenesis in rat zona fasciculata-reticularis cells. Adapt. Med. 4: 75-80, 2012.
3 Pu, H.F., Lin, C.W., Lee, H.W., and Wang, P.S.* Effects of propylthiouracil on the production of aldosterone in rat zona glomerulosa cells. Adapt. Med. 4: 245-250, 2012.
4 Chang, L.L.*, Wun, W.S.A., and Wang P.S.In utero and neonate exposure to nonylphenol develops hyperadrenalism and metabolic syndrome later in life. I. First generation rats (F1). Toxicology 301: 40-49, 2012. (* Equal Contributions)
5 Chang, F.Y.*, Lu, C.L., Chen, T.S., and Wang, P.S. The role of cholecystokinin 1 receptor in prolactin inhibited gastric emptying of male rat. J. Neurogastroenterol. Motil. 18:385-390, 2012.
6 Chang, J.W., Tsai, H.L., Chen, C.W., Yang, H.W., Yang, A.H., Yang, L.Y., Wang, P. S., Ng, Y.Y., Lin, T.L. and Lee, O.K.* Conditioned mesenchymal stem cells attenuate progression of chronic kidney disease through inhibition of epithelial-to-mesenchymal transition and immune modulation. J. Cell. Mol. Med. 16:2935-2949, 2012.
7 Wang, K.L., Hsia, S.M., Chan, C.J., Huang, C.Y., Bau, D.T., Chang, F.Y., and Wang, P.S.* Inhibitory effects of isoliquiritigenin on the migration and invasion of human breast cancer cells. Expert Opin. Ther. Tar. 17: 337-349, 2013.
8 Bau, D.T.*, Pu, H.F., Tsai, C.W., and Wang, P.S. Steady progresses of the Chinese Journal of Physiology in 2011. Chinese J. Physiol. 56: 58-60, 2013.
9 Chuang, T.Y., Chang, F.Y., Juan, C.C., and Wang, P.S.* Adaptive roles of adiponectin and resistin in cardiovascular disease. Adapt. Med. 5: 21-28, 2013.
10 Chang, H.C., Yang, Y.R., Wang, P.S., Kuo, C.H., and Wang, R.Y.* The neuroprotective effects of intramuscular insulin-like growth factor-1 treatment in brain ischemic rats. PLoS ONE 8:e64015, 2013.
11 Wang, K.L., Hsia, S.M., Yeh, J.Y., Cheng, S.C. Wang, P.S.*, and Wang, S.W.* Anti-proliferative effects of evodiamine on human breast cancer cells. PLoS ONE 8: e67297, 2013.
12 Chang, L.L.*, Wun W.S., and Wang, P.S.* Recovery from developmental nonylphenol exposure is possible I. Male. J. Biol. Agricul. Healthc. 3:118-130, 2013.
13 Hwang, G.S., Hu, S., Lin, Y.H., Chen, S.T., Tang, T.K., Wang, P.S.*, and Wang, S.W.* Arecoline inhibits interleukin-2 secretion in jurkat cells by decreasing the expression of cyclooxygenase-2, alpha7-nicotinic acetylcholine receptors and prostaglandin E2. J. Physiol. Pharmacol. 64:535-543, 2013.
14 Lin, C.S., Pei , K.J.C. *, Wang, P.S., and B.T. Liu. Evidence of higher levels of testosterone during the velvet period in muntjac than in other cervids. Theriogenology 81: 403-406, 2014.
15 Lieu, F.K., Lin, C.Y., Wang, P.S., Jian, C.Y., Yeh, Y.H., Chen, Y.A., Wang, K.L., Lin, Y.C., Chang, L.L., Wang, G.J., and Wang, S.W.* Effect of swimming on the production of aldosterone in rats. PLoS ONE (In Press)
16 Chang, H.C., Yang, Y.R., Wang, P.S., and Wang, R.Y.* Quercetin enhances exercise- mediated neuroprotective effects in brain ischemic rats. Med. Sci. Sports Exer. 46: 1908-1916, 2014.
17 Chang, Y.J., Hwu, C.M., Yeh, C.C., Wang, P.S.*and Wang, S.W.* Subacute hypothyroidism on metabolism and growth-related molecules. Molecules. 19: 11178-11195, 2014.
18 Wang, Z.H., Hsu, H.W., Chou, J.C., Yu C.H., Bau, D.T., Wang, G.J., Huang C.Y., Wang, P.S., and Wang, S.W.* Cytotoxic effect of S-petasin and iso-S-petasin on the proliferation of human prostate cancer cells. Anticancer Res. 35:191-199, 2015.
19 Weng, T.C. and Wang, P.S.* Biological regulation of aging process. Adapt. Med. 7: 18-25, 2015.
20 Wang, K.L., Hsia, S.M., Chang, Y.C., Chou, J.C., Lieu, F.K., Tsai, P.C., Wang, S.W.*, and Wang, P.S.* Adaptation of testosterone production in response to low-dose effects of nonylphenol. Adapt. Med. 7: 44-51, 2015.
21 Manfo, F.P.T. *, Nantia, E.A., Beboy, S.N.E., Moundipa, P.F., Pugeat, M., and Wang, P.S. Medicinal plants as treatment option of male reproductive dysfunction. Adapt. Med. 7:57-72, 2015.
22 Yu, P.L., Cheng, S.Y., Chou J.C., Pan, W.H.T., Wang, S.W.,* and Wang, P.S.* Regulation of intermittent hypoxia on brain dopamine in amphetaminized rats. Chinese J. Physiol. 58:219-227, 2015.
23 Chang, Y.J., Wang, P.S., Wang, S.W.,* and Hwu, C.M.* Effect of liquid formula on plasma glucose, insulin, and ghrelin levels in healthy humans with mixed meal tests. Adapt. Med. 8:24-31, 2016.
24 Yeh, J.Y., Chiao, Y.C., Lin, H., and Wang, P.S.* Involvement of cholecystokinin (CCK) receptor in the adaptation of gastric emptying induced by adrenocorticotropin (ACTH) in male rats. Adapt. Med. 8:40-44, 2016.
25 Chang, L. L., Wun, W.S.A., and Wang, P.S.* Nonylphenol-induced hyperadrenalism can be reversed/ alleviated by inhibiting of II-β hydroxysteroid dehydroglnase type I. Environ. Toxicol. Pharmacol. 44: 1-12, 2016.
26 Chou, J.C., Kan, S.F., Lieu, F.K., Soong, C., Tsai, S.C., Lin, C.Y., Wang, P.S.* and Wang, S.W.* Inhibitory effects of propylthiouracil on corticosterone production in rat zona fasciculata-reticularis cells. Pharmacologia 7(2-3): 83-92, 2016.
27 Wang, K.L., Huang, W.C., Chou, J.C., Weng, T.C., Hu, S., Lieu, F.K., Lai, W.H., Idova, G., Wang, P.S.,* and Wang, S.W*. Effects of acrolein on aldosterone release from zona glomerulosa cells in male rats. Steroids 111: 89-94, 2016.
28 Yeh, Y.H., Chou, J.C., Weng, T.C., Lieu, F.K., Lin, J.Y., Yeh, C.C., Hu, S., Wang, P.S.,* Idova, G., and Wang, S.W.* Effects of acrolein on the production of corticosterone in male rats. Steroids 111:139-147, 2016.
29 Chen, C.W., Jian, C.Y., Lin, P.H., Chen C.C., Lieu, F.K., Soong, C., Hsieh, C.C., Wan, C.Y., Idova, G., Hu, S., Wang, S.W.,* and Wang, P.S.* Role of testosterone in regulating induction of TNF-α in rat spleen via ERK signaling pathway. Steroids 111: 148-154, 2016.
30 Wang, P.S. and Chang, L.L.* Effects of nonylphenol on hyperadrenalism and metabolism in male rats. J. Metab. Invest. 2:e1379, 2016.
31 Lin, P.H., Jian, C.Y., Chou, J.C., Chen, C.W., Chen, C.C., Soong, C., Hu, S., Lieu, F.K.*, Wang, P.S.*, and Wang S.W*. Induction of renal senescence marker protein-30 (SMP30) expression by testosterone and its contribution to urinary calcium absorption in male rats. Sci. Rep.6: 32085, 2016
32 Chen, C.W., Chen, C.C., Jian, C.Y., Lin, P.H., Chou, J.C., Teng H.S., Hu, S., Lieu, F.K., Wang, P.S.*, and Wang, S.W. Attenuation of exercise effect on inflammatory responses via novel role of TLR4/PI3K/Akt signaling in rat splenocytes J. Appl. Physiol. 2016 [in press]
33 Chen, C.W., Hu, S., Wang, P.S., Hwu, C.M., and Wang, S.W. Testosterone as a regulator of immune system via modulation of toll-like receptor 4/extracellular signal-regulated kinase signaling pathway. Inflamm. Cell Signal. 3: e1407, 2016.

Research grant: 

1.     Effects of Acrolein and Nicotine on the Secretion of Testosterone In Vivo and In Vitro

2.     Effects of Pyruvate on Gastrointestinal Motility and Hormone Secretion in Male Rats

3.     Toxicological Effects of Polybrominated Diphenyl Ethers ( PBDEs ) Exposure on Endocrine and Immune Systems in

4.     Toxicological Effects of Polybrominated Diphenyl Ethers ( PBDEs ) Exposure on Endocrine and Immune Systems in

5.     Effects of Hypoxia on the Production of Testosterone from TM3 and Rat Leydig Cells

6.     Effects of Food Intake, Insulin, and Thyroid Hormones on the Expression of Ghrelin in Male Rats

Lab membership:

Master Student: 

Ph.D. Student: Chien-Wei Chen, Chih-Chieh Chen, Po-Han Lin, Chia-Hung Sun, Chi-Hung Ho, Cai-Yun Jian

Research Assistant: 

Post Doctoral Fellows: 


2013 Annual Meeting of the SSR, Montréal Canada

2012 Annual Meeting of the SSR, Pennsylvania , U.S.A

2011 Annual Meeting of the SSR, Portland , U.S.A

2011 Satellite Symposia of FAOPS, Taipei, Taiwan


Voice Play